User profiles for M D Tobin

Martin D Tobin

University of Leicester
Verified email at leicester.ac.uk
Cited by 64888

Key concepts in genetic epidemiology

PR Burton, MD Tobin, JL Hopper - The Lancet, 2005 - thelancet.com
This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …

Genomic copy number variation, human health, and disease

LV Wain, JAL Armour, MD Tobin - The Lancet, 2009 - thelancet.com
Despite the long recognised effects of chromosomal structural abnormalities and completion
of the Human Genome Project, much of the structural variation in the genome has gone …

[HTML][HTML] Genomewide association analysis of coronary artery disease

…, C Gieger, P Deloukas, MD Tobin… - … England Journal of …, 2007 - Mass Medical Soc
Background Modern genotyping platforms permit a systematic search for inherited components
of complex diseases. We performed a joint analysis of two genomewide association …

Genome-wide association study identifies eight loci associated with blood pressure

C Newton-Cheh, T Johnson, V Gateva, MD Tobin… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Identification of seven loci affecting mean telomere length and their association with disease

…, X Xiao, DJ Van Veldhuisen, AL Catapano, MD Tobin… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure

MD Tobin, NA Sheehan, KJ Scurrah… - Statistics in …, 2005 - Wiley Online Library
A population‐based study of a quantitative trait may be seriously compromised when the trait
is subject to the effects of a treatment. For example, in a typical study of quantitative blood …

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

…, B Zhu, L Song, L Kachuri, MS Artigas, MD Tobin… - Nature …, 2017 - nature.com
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

…, JA Todd, D Easton, DG Clayton, PR Burton, MD Tobin… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …

Genome-wide association study identifies five loci associated with lung function

…, DM Evans, P Elliott, DP Strachan, IP Hall, MD Tobin - Nature …, 2010 - nature.com
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

…, NJ Samani, JMM Howson, MD Tobin… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …