User profiles for M D Tobin
Martin D TobinUniversity of Leicester Verified email at leicester.ac.uk Cited by 64888 |
Key concepts in genetic epidemiology
This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …
and topical issues in modern genetic epidemiology. In this article, we provide an overall …
Genomic copy number variation, human health, and disease
Despite the long recognised effects of chromosomal structural abnormalities and completion
of the Human Genome Project, much of the structural variation in the genome has gone …
of the Human Genome Project, much of the structural variation in the genome has gone …
[HTML][HTML] Genomewide association analysis of coronary artery disease
…, C Gieger, P Deloukas, MD Tobin… - … England Journal of …, 2007 - Mass Medical Soc
Background Modern genotyping platforms permit a systematic search for inherited components
of complex diseases. We performed a joint analysis of two genomewide association …
of complex diseases. We performed a joint analysis of two genomewide association …
Genome-wide association study identifies eight loci associated with blood pressure
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …
To date, identification of common genetic variants influencing blood pressure has proven …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure
MD Tobin, NA Sheehan, KJ Scurrah… - Statistics in …, 2005 - Wiley Online Library
A population‐based study of a quantitative trait may be seriously compromised when the trait
is subject to the effects of a treatment. For example, in a typical study of quantitative blood …
is subject to the effects of a treatment. For example, in a typical study of quantitative blood …
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
…, JA Todd, D Easton, DG Clayton, PR Burton, MD Tobin… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …