Bioconductor is an open-source, open-development software project for the analysis and
comprehension of high-throughput data in genomics and molecular biology. The project aims …

Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in
combination with a cosurfactant. These systems are currently of interest to the …

Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life
mirror those of one of the most common cause of death—metastatic cancer. Epithelial to …

Major international projects are underway that are aimed at creating a comprehensive catalogue
of all the genes responsible for the initiation and progression of cancer 1 , 2 , 3 , 4 , 5 , 6 …

The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in
glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

We describe Bioconductor infrastructure for representing and computing on annotated genomic
ranges and integrating genomic data with the statistical computing features of R and its …

… We declare m to be a candidate variant if the log-likelihood ratio of the data under the
variant and reference models (that is, the log odds (LOD) score) exceeds a predefined decision …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …