Case definition and phenotype standardization in drug‐induced liver injury
…, RJ Andrade, D Larrey, M Molokhia… - Clinical …, 2011 - Wiley Online Library
Drug‐induced liver injury (DILI) is the most frequent reason cited for the withdrawal of
approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. …
approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. …
Efficacy and harms of direct oral anticoagulants in the elderly for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism …
… Dr Molokhia has received previous grants from AstraZeneca, Pfizer, and the Serious Adverse
Events Consortium for drug safety studies unrelated to this work. The other authors report …
Events Consortium for drug safety studies unrelated to this work. The other authors report …
Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials
“Mendelian randomization” refers to the random assortment of genes transferred from
parent to offspring at the time of gamete formation. This process has been compared to a …
parent to offspring at the time of gamete formation. This process has been compared to a …
[HTML][HTML] Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Background Previous attempts to characterise the burden of chronic respiratory diseases
have focused only on specific disease conditions, such as chronic obstructive pulmonary …
have focused only on specific disease conditions, such as chronic obstructive pulmonary …
[HTML][HTML] HLA-A* 3101 and carbamazepine-induced hypersensitivity reactions in Europeans
…, K Chinthapalli, M Molokhia… - … England Journal of …, 2011 - Mass Medical Soc
Background Carbamazepine causes various forms of hypersensitivity reactions, ranging from
maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been …
maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been …
Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK …
Objective To investigate the risk of incident myocardial infarction, congestive heart failure,
and all cause mortality associated with prescription of oral antidiabetes drugs. Design …
and all cause mortality associated with prescription of oral antidiabetes drugs. Design …
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles
BACKGROUND & AIMS: Drug-induced liver injury (DILI), especially from antimicrobial agents,
is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a leading …
is an important cause of serious liver disease. Amoxicillin-clavulanate (AC) is a leading …
[HTML][HTML] Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding
to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated …
to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated …
[HTML][HTML] Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss
M Salker, G Teklenburg, M Molokhia, S Lavery, G Trew… - PloS one, 2010 - journals.plos.org
Background Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages,
is widely attributed either to repeated chromosomal instability in the conceptus or to …
is widely attributed either to repeated chromosomal instability in the conceptus or to …
[HTML][HTML] Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation
G Teklenburg, M Salker, M Molokhia, S Lavery, G Trew… - PloS one, 2010 - journals.plos.org
Background Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated
by locally secreted factors between a developmentally competent embryo and a receptive …
by locally secreted factors between a developmentally competent embryo and a receptive …