Since their first description, extracellular vesicles (EVs) have been the topic of avid study in a
variety of physiologic contexts and are now thought to play an important role in cancer. The …

This review describes the anatomy of the articular surfaces and their movement in the normal
tibio-femoral joint, together with methods of measurement in volunteers. Forces and soft …

Background Quantification of the disease burden caused by different risks informs
prevention by providing an account of health loss different to that provided by a disease-by-disease …

Importance Understanding the major health problems in the United States and how they are
changing over time is critical for informing national health policy. Objectives To measure the …

Background Reliable and timely information on the leading causes of death in populations,
and how these are changing, is a crucial input into health policy debates. In the Global …

Background Non-fatal health outcomes from diseases and injuries are a crucial consideration
in the promotion and monitoring of individual and population health. The Global Burden of …

Background Measuring disease and injury burden in populations requires a composite metric
that captures both premature mortality and the prevalence and severity of ill-health. The …

Importance Tobacco is a leading global disease risk factor. Understanding national trends in
prevalence and consumption is critical for prioritizing action and evaluating tobacco control …

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