User profiles for M. S. Lawrence
Michael S. LawrenceMassachusetts General Hospital Verified email at mgh.harvard.edu Cited by 199059 |
The landscape of somatic copy-number alteration across human cancers
…, H Greulich, M Reich, W Winckler, MS Lawrence… - Nature, 2010 - nature.com
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
[PDF][PDF] The immune landscape of cancer
…, J Kim, MS Lawrence, P Lin, S Meier, MS Noble… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …
[PDF][PDF] Integrated genomic characterization of papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Detection of somatic point substitutions is a key step in characterizing the cancer genome.
However, existing methods typically miss low-allelic-fraction mutations that occur in only a …
However, existing methods typically miss low-allelic-fraction mutations that occur in only a …
[PDF][PDF] Oncogenic signaling pathways in the cancer genome atlas
…, J Kim, MS Lawrence, P Lin, S Meier, MS Noble… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…
[PDF][PDF] The molecular taxonomy of primary prostate cancer
…, PH Lai, PW Laird, ES Lander, M Latour, MS Lawrence… - Cell, 2015 - cell.com
There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …
[PDF][PDF] Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
…, J Kim, R Kucherlapati, PH Lai, MS Lawrence… - Cell, 2016 - cell.com
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …
glioma driving alterations and suboptimal disease classification. We defined the complete …
[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
…, J Kim, MS Lawrence, P Lin, S Meier, MS Noble… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …
[PDF][PDF] Comprehensive molecular portraits of invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …
[PDF][PDF] Comprehensive characterization of cancer driver genes and mutations
…, DI Heiman, MS Lawrence, P Lin, S Meier, MS Noble… - Cell, 2018 - cell.com
Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on …
algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on …