BackgroundStudies of the long-term course and outcome of psychoses tend to focus on cohorts
of prevalent cases. Such studies bias samples towards those with poor outcomes, which …

BackgroundWe examined longitudinally the course and predictors of treatment resistance in
a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic …

The excess mortality in people with psychotic disorders is a major public health concern, but
little is known about the clinical and social risk factors which may predict this health …

Background: Validity of current International Classification of Disease/Diagnostic and Statistical
Manual of Mental Disorders (ICD/DSM) first episode psychosis diagnoses is essential in …

It has long been held that schizophrenia and other psychotic disorders have a predominately
poor course and outcome. We have synthesized information on mortality, clinical and …

BackgroundA lack of an aetiologically based nosology classification has contributed to instability
in psychiatric diagnoses over time. This study aimed to examine the diagnostic stability …

BackgroundThere is evidence from North American trials that supported employment using
the individual placement and support (IPS) model is effective in helping individuals with …

BackgroundGrowing evidence suggests that air pollution exposure may adversely affect the
brain and increase risk for psychiatric disorders such as schizophrenia and depression. …

Background: Multiple sclerosis (MS) is a chronic condition that affects quality of life (QOL),
leads to disability and requires ongoing care inputs. Few studies have examined the impact of …

Background The incidence of psychotic disorders is elevated in some minority ethnic
populations. However, we know little about the outcome of psychoses in these populations. Aims …