User profiles for Mary R Cahill

Mary R Cahill

University College Cork
Verified email at hse.ie
Cited by 5159

Platelets circulate in an activated state in inflammatory bowel disease

CE Collins, MR Cahill, AC Newland, DS Rampton - Gastroenterology, 1994 - Elsevier
Background/Aims: Platelets show proinflammatory as well as prothrombotic properties.
Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, …

A novel 33‐Gene targeted resequencing panel provides accurate, clinical‐grade diagnosis and improves patient management for rare inherited anaemias

…, S Okoli, W Atoyebi, A Mixon, MR Cahill… - British journal of …, 2016 - Wiley Online Library
Accurate diagnosis of rare inherited anaemias is challenging, requiring a series of complex
and expensive laboratory tests. Targeted next‐generation‐sequencing ( NGS ) has been …

[HTML][HTML] The effectiveness of interventions to improve laboratory requesting patterns among primary care physicians: a systematic review

…, JP Browne, CP Bradley, MR Cahill - Implementation Science, 2015 - Springer
Background Laboratory testing is an integral part of day-to-day primary care practice, with
approximately 30 % of patient encounters resulting in a request. However, research suggests …

A multi‐centre retrospective study of rituximab use in the treatment of relapsed or resistant warm autoimmune haemolytic anaemia

…, HM O'Leary, I Khan, MR Cahill… - British journal of …, 2013 - Wiley Online Library
This retrospective analysis assessed the response, safety and duration of response to standard
dose rituximab 375 mg/m 2 weekly for four weeks as therapy for patients with primary or …

Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic …

…, TG Cotter, SL McKenna, MR Cahill… - Molecular …, 2017 - ACS Publications
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults and is
associated with high relapse rates. It is known that leukemia stem cells (LSCs), a very small …

[HTML][HTML] Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic …

…, MJ Nyhan, A Britschgi, MP Tschan, MR Cahill… - Experimental …, 2015 - Elsevier
Highlights • Autophagy is increased during all-trans-retinoic acid-induced differentiation of
NB4 leukemia cells. • Inhibition (small hairpin RNA) of an essential autophagy gene ATG7 …

Duration of increased bleeding tendency after cessation of aspirin therapy

RA Cahill, GT McGreal, BH Crowe… - Journal of the …, 2005 - journals.lww.com
Background Aspirin has a significant effect on hemostasis, so it is often recommended that
patients taking aspirin discontinue treatment before elective surgery. While off aspirin, these …

Induction of autophagy by Imatinib sequesters Bcr‐Abl in autophagosomes and down‐regulates Bcr‐Abl protein

…, LC Crowley, TR O'Donovan, MR Cahill… - American journal of …, 2013 - Wiley Online Library
Chronic Myeloid Leukemia (CML) is a disease of hematopoietic stem cells which harbor the
chimeric gene Bcr‐Abl. Expression levels of this constitutively active tyrosine kinase are …

Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation

…, J Timoney, C O'Connor, MR Cahill… - Blood, The Journal …, 2014 - ashpublications.org
The loss of regulation of cell proliferation is a key event in leukemic transformation, and the
oncogene tribbles (Trib)2 is emerging as a pivotal target of transcription factors in acute …

All‐trans retinoic acid (ATRA)‐induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL)

N Orfali, TR O'Donovan, MR Cahill… - European journal of …, 2020 - Wiley Online Library
Objective In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by
an abnormal PML‐RARα fusion oncoprotein, leading to a block in cell differentiation. …