Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis

MW Lorenz, HS Markus, ML Bots, M Rosvall, M Sitzer - Circulation, 2007 - Am Heart Assoc
Background— Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker
for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end …

Improvements in risk stratification for the occurrence of cardiovascular disease by imaging subclinical atherosclerosis: a systematic review

SAE Peters, HM den Ruijter, ML Bots, KGM Moons - Heart, 2012 - heart.bmj.com
Context Imaging for subclinical atherosclerosis on top of conventional risk factor assessment
may improve risk prediction for the occurrence of cardiovascular disease events in …

Measurement of carotid intima–media thickness to assess progression and regression of atherosclerosis

…, MC Meuwese, F Akdim, ML Bots… - Nature clinical practice …, 2008 - nature.com
Imaging modalities have been developed to assess atherosclerosis in vivo in the arterial
wall because large clinical end-point studies are time-consuming and costly. Historically, in-…

Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study

ML Bots, AW Hoes, PJ Koudstaal, A Hofman… - Circulation, 1997 - Am Heart Assoc
Background Noninvasive assessment of intima-media thickness (IMT) is widely used in
observational studies and trials as an intermediate or proxy end point for cardiovascular disease. …

Genome-wide association study identifies eight loci associated with blood pressure

…, S Polidoro, DE Grobbee, NC Onland-Moret, ML Bots… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

[HTML][HTML] Simvastatin with or without ezetimibe in familial hypercholesterolemia

…, ESG Stroes, AH Zwinderman, ML Bots… - … England Journal of …, 2008 - Mass Medical Soc
Background Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density
lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on …

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

A Hofman, A Ott, MMB Breteler, ML Bots, AJC Slooter… - The Lancet, 1997 - thelancet.com
Background Vascular disorders have been implicated in dementia, but whether atherosclerosis
is related to the most frequent type of dementia, Alzheimer's disease, is not known. The …

Association between arterial stiffness and atherosclerosis: the Rotterdam Study

NM Van Popele, DE Grobbee, ML Bots, R Asmar… - Stroke, 2001 - Am Heart Assoc
Background and Purpose—Studies of the association between arterial stiffness and
atherosclerosis are contradictory. We studied stiffness of the aorta and the common carotid artery in …

Peripheral arterial disease in the elderly: The Rotterdam Study

WT Meijer, AW Hoes, D Rutgers, ML Bots… - … , and vascular biology, 1998 - Am Heart Assoc
To assess the age- and sex-specific prevalence of peripheral arterial disease (PAD) and
intermittent claudication (IC) in an elderly population, we performed a population-based study …

Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial

…, MK Palmer, DH O'Leary, DE Grobbee, ML Bots… - Jama, 2007 - jamanetwork.com
ContextAtherosclerosis is often advanced before symptoms appear and it is not clear whether
treatment is beneficial in middle-aged individuals with a low Framingham risk score (FRS) …