Diabetes mellitus is a chronic disorder of glucose metabolism with serious clinical
consequences. The multi-system complications of diabetes include microvascular (retinopathy, …

Despite much progress with physical activity assessment, the limitations concerning the
accurate measurement of physical activity are often amplified in young people due to the …

2020 will go down in history as the year when the global community was awakened to the
fragility of human health and the interdependence of the ecosystem, economy, and humanity. …

Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …

Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene
encoding leptin 1 , an adipocyte-specific secreted protein which has profound effects on appetite …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …