Background Moderate-to-severe hemophilia B is treated with lifelong, continuous coagulation
factor IX replacement to prevent bleeding. Gene therapy for hemophilia B aims to establish …

Although the pathophysiology underlying severe COVID19 remains poorly understood,
accumulating data suggest that a lung‐centric coagulopathy may play an important role. …

… NG DUFFIELD AND NEIL O'CONNELL that the upper bound estimates which they obtain
via martingale methods are asymptotically correct. We also consider a non-Gaussian example, …

Background This is an updated version of the original Cochrane Review published in 2010,
Issue 9, and last updated in 2014, Issue 4. Non‐invasive brain stimulation techniques aim to …

Background Persistent symptoms including breathlessness, fatigue, and decreased exercise
tolerance have been reported in patients after acute SARS‐CoV‐2 infection. The biological …

Three hundred and twenty pigs were reared from birth to slaughter at 21 weeks in either barren
or enriched environments. The barren environments were defined as intensive housing (…

There is increasing evidence that chronic pain problems are characterised by alterations in
brain structure and function. Chronic back pain is no exception. There is a growing sentiment…

Background Persistent fatigue, breathlessness, and reduced exercise tolerance have been
reported following acute COVID‐19 infection. Although immuno‐thrombosis has been …

Background There is currently no strong consensus regarding the optimal management of
complex regional pain syndrome although a multitude of interventions have been described …

We describe a metabolic defect in bile acid synthesis involving a deficiency in 7alpha-hydroxylation
due to a mutation in the gene for the microsomal oxysterol 7alpha-hydroxylase …