User profiles for Naveen S Vasudev
 | Naveen VasudevLeeds Institute of Medical Research at St James's Verified email at leeds.ac.uk Cited by 3449 |
[HTML][HTML] Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions
NS Vasudev, AR Reynolds - Angiogenesis, 2014 - Springer
Tumours require a vascular supply to grow and can achieve this via the expression of pro-angiogenic
growth factors, including members of the vascular endothelial growth factor (VEGF…
growth factors, including members of the vascular endothelial growth factor (VEGF…
Vessel co‐option is common in human lung metastases and mediates resistance to anti‐angiogenic therapy in preclinical lung metastasis models
…, EA Kuczynski, NS Vasudev… - The Journal of …, 2017 - Wiley Online Library
Anti‐angiogenic therapies have shown limited efficacy in the clinical management of metastatic
disease, including lung metastases. Moreover, the mechanisms via which tumours resist …
disease, including lung metastases. Moreover, the mechanisms via which tumours resist …
(−)‐Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels
…, MS Amer, A Bruns, NS Vasudev… - Angewandte Chemie …, 2015 - Wiley Online Library
Current therapies for common types of cancer such as renal cell cancer are often ineffective
and unspecific, and novel pharmacological targets and approaches are in high demand. …
and unspecific, and novel pharmacological targets and approaches are in high demand. …
[HTML][HTML] Variation in genomic landscape of clear cell renal cell carcinoma across Europe
The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is
particularly high in some parts of Central Europe. Here we undertake whole-genome and …
particularly high in some parts of Central Europe. Here we undertake whole-genome and …
Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with …
NS Vasudev, M Wilson, GD Stewart, A Adeyoju… - BMJ open, 2020 - bmjopen.bmj.com
Objectives To describe the frequency and nature of symptoms in patients presenting with
suspected renal cell carcinoma (RCC) and examine their reliability in achieving early diagnosis…
suspected renal cell carcinoma (RCC) and examine their reliability in achieving early diagnosis…
[HTML][HTML] Renal cancer biomarkers: the promise of personalized care
NS Vasudev, PJ Selby, RE Banks - BMC medicine, 2012 - Springer
Significant advances in our understanding of the biology of renal cell carcinoma (RCC) have
been achieved in recent years. These insights have led to the introduction of novel targeted …
been achieved in recent years. These insights have led to the introduction of novel targeted …
[HTML][HTML] Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells
M Gourlaouen, JC Welti, NS Vasudev… - Journal of Biological …, 2013 - ASBMB
Vascular endothelial growth factor (VEGF) stimulates angiogenesis by binding to VEGF
receptor 2 (VEGFR2) on endothelial cells (ECs). Downstream activation of the extracellular …
receptor 2 (VEGFR2) on endothelial cells (ECs). Downstream activation of the extracellular …
[HTML][HTML] Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma
Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered
novel driver genes and pathways. Given the unequal incidence rates among men and …
novel driver genes and pathways. Given the unequal incidence rates among men and …
[HTML][HTML] Long-term outcomes of image-guided ablation and laparoscopic partial nephrectomy for T1 renal cell carcinoma
…, NS Vasudev, C Ralph, S Jagdev, S Bhattarai… - European …, 2022 - Springer
… Furthermore, in contrast to the EAU’s guidance [7], our results have shown that recurrences
after 5 years may have been more common than usually perceived, with five recurrences …
after 5 years may have been more common than usually perceived, with five recurrences …
[HTML][HTML] Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics
HJ Gaunt, NS Vasudev, DJ Beech - European Biophysics Journal, 2016 - Springer
Novel approaches towards cancer therapy are urgently needed. One approach might be to
target ion channels mediating Ca 2+ entry because of the critical roles played by Ca 2+ in …
target ion channels mediating Ca 2+ entry because of the critical roles played by Ca 2+ in …