CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

…, DNC Jones, S Lovestone, D Gómez-Nicola… - Brain, 2019 - academic.oup.com
Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease
pathology. Recent genome-wide association studies have highlighted multiple immune-…

[HTML][HTML] Inflammatory biomarkers in Alzheimer's disease plasma

…, VH Perry, M Cleal, G Fryatt, D Gomez-Nicola… - Alzheimer's & …, 2019 - Elsevier
Introduction Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy
Grail” of AD research and intensively sought; however, there are no well-established …

[HTML][HTML] A modest increase in 11C-PK11195-positron emission tomography TSPO binding in depression is not associated with serum C-reactive protein or body mass …

…, L Winchester, M Cleal, D Gomez-Nicola… - Biological Psychiatry …, 2021 - Elsevier
Background Immune mechanisms have been implicated in the pathogenesis of depression.
Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used …

The Winchcombe meteorite, a unique and pristine witness from the outer solar system

…, NE Bowles, FM Stuart, L Di Nicola, D Györe… - Science …, 2022 - science.org
Direct links between carbonaceous chondrites and their parent bodies in the solar system are
rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite …

Microglia states and nomenclature: A field at its crossroads

…, F Ginhoux, CK Glass, O Gokce, D Gomez-Nicola… - Neuron, 2022 - cell.com
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

[HTML][HTML] Genomic classification and prognosis in acute myeloid leukemia

…, S O'Meara, K Raine, DR Jones… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …

Defining microglial states and nomenclature: a roadmap to 2030

…, F Ginhoux, CK Glass, O Gokce, D Gomez-Nicola… - 2022 - papers.ssrn.com
Microglial research has been constrained by a rolling series of dichotomies such as “resting
versus activated” or “M1 versus M2”. This Manichean perspective of good or bad microglia is …

[HTML][HTML] Mutational signatures of ionizing radiation in second malignancies

…, KM Raine, L Stebbings, A Menzies, D Jones… - Nature …, 2016 - nature.com
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The
signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation …

Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

…, F Karpe, MJ Neville, M Andersson, AJ Brent, N Jones… - elife, 2020 - elifesciences.org
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic
staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for …

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

…, L Le Bourhis, IG Boneca, A Allaoui, NL Jones… - Nature …, 2010 - nature.com
D. melanogaster cells 44 . This autophagy response is required for the control of L. …
monocytogenes 10403S and the listeriolysin O deletion mutant were from D. Portnoy… Nicola L …