CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
…, DNC Jones, S Lovestone, D Gómez-Nicola… - Brain, 2019 - academic.oup.com
Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease
pathology. Recent genome-wide association studies have highlighted multiple immune-…
pathology. Recent genome-wide association studies have highlighted multiple immune-…
[HTML][HTML] Inflammatory biomarkers in Alzheimer's disease plasma
…, VH Perry, M Cleal, G Fryatt, D Gomez-Nicola… - Alzheimer's & …, 2019 - Elsevier
Introduction Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy
Grail” of AD research and intensively sought; however, there are no well-established …
Grail” of AD research and intensively sought; however, there are no well-established …
[HTML][HTML] A modest increase in 11C-PK11195-positron emission tomography TSPO binding in depression is not associated with serum C-reactive protein or body mass …
…, L Winchester, M Cleal, D Gomez-Nicola… - Biological Psychiatry …, 2021 - Elsevier
Background Immune mechanisms have been implicated in the pathogenesis of depression.
Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used …
Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used …
The Winchcombe meteorite, a unique and pristine witness from the outer solar system
Direct links between carbonaceous chondrites and their parent bodies in the solar system are
rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite …
rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite …
Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …
[HTML][HTML] Genomic classification and prognosis in acute myeloid leukemia
…, S O'Meara, K Raine, DR Jones… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …
Defining microglial states and nomenclature: a roadmap to 2030
Microglial research has been constrained by a rolling series of dichotomies such as “resting
versus activated” or “M1 versus M2”. This Manichean perspective of good or bad microglia is …
versus activated” or “M1 versus M2”. This Manichean perspective of good or bad microglia is …
[HTML][HTML] Mutational signatures of ionizing radiation in second malignancies
…, KM Raine, L Stebbings, A Menzies, D Jones… - Nature …, 2016 - nature.com
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The
signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation …
signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation …
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study
…, F Karpe, MJ Neville, M Andersson, AJ Brent, N Jones… - elife, 2020 - elifesciences.org
We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic
staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for …
staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for …
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
…, L Le Bourhis, IG Boneca, A Allaoui, NL Jones… - Nature …, 2010 - nature.com
… D. melanogaster cells 44 . This autophagy response is required for the control of L. …
monocytogenes 10403S and the listeriolysin O deletion mutant were from D. Portnoy… Nicola L …
monocytogenes 10403S and the listeriolysin O deletion mutant were from D. Portnoy… Nicola L …