AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary
scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio 1 . Recent …

Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with
reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan…

The ubiquitin-proteasome pathway plays a critical role in the regulated degradation of proteins
involved in cell cycle control and tumor growth. Dysregulating the degradation of such …

Calorie restriction extends lifespan and produces a metabolic profile desirable for treating
diseases of ageing such as type 2 diabetes 1 , 2 . SIRT1, an NAD + -dependent deacetylase, …

Human multiple myeloma (MM) is a presently incurable hematological malignancy, and novel
biologically based therapies are urgently needed. Proteasome inhibitors represent a novel …

A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related
diseases in laboratory animals is greatly sought after. We and others have shown that …

… For an alternative treatment see the author's paper (Elliott [16]). In fact a satisfactory analysis
of the limiting behaviour of the frequencies (10) may be carried out assuming only that the …

PURPOSE: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and
pharmacodynamics (PD) of the proteasome inhibitor bortezomib (previously known as PS-…

The NAD + -dependent deacetylase SIRT1 controls metabolic processes in response to low
nutrient availability. We report the metabolic phenotype of mice treated with SRT1720, a …

Multicomponent therapies, originating through deliberate mixing of drugs in a clinical setting,
through happenstance, and through rational design, have a successful history in a number …