OBJECTIVE The antidiabetic properties of metformin are mediated through its ability to
activate the AMP-activated protein kinase (AMPK). Activation of AMPK can suppress tumor …

Background Corticosteroids and antiviral agents are widely used to treat the early stages of
idiopathic facial paralysis (ie, Bell's palsy), but their effectiveness is uncertain. Methods We …

Aims To evaluate the patterns and predictors of adherence in all patients with Type 2 diabetes
in the community receiving treatment with a single oral hypoglycaemic drug. In particular, …

Background The prevalence of male obesity is increasing but few men take part in weight
loss programmes. We assessed the effect of a weight loss and healthy living programme on …

Increasing duration of tamoxifen therapy improves survival in women with breast cancer but
the impact of adherence to tamoxifen on mortality is unclear. This study investigated whether …

Background: Adjuvant endocrine therapy is recommended for women with oestrogen
receptor-positive breast cancer, but many women do not take the medication as directed and they …

Objective To evaluate prevalence and incidence of diagnosed primary hyperparathyroidism
(PHPT) in adults between 1997 and 2006 in Tayside, Scotland, UK. Design Population‐…

Background Non-steroidal anti-inflammatory drugs (NSAIDs) are a common cause of adverse
drug events (ADEs), but renal risks of NSAIDs are less well quantified than gastrointestinal …

Background Glycaemic control in women with diabetes is critical to satisfactory pregnancy
outcome. A systematic review of two randomised trials concluded that there was no clear …

Objective To evaluate effects of remote monitoring of adjuvant chemotherapy related side
effects via the Advanced Symptom Management System (ASyMS) on symptom burden, quality …