Type 2 diabetes is now epidemic. In the US, there has been a 61% increase in incidence
between 1990 and 2001 (1). There are currently 1.5 million new cases per year, and the …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

Recent research has shown that adi-pose tissue is not simply an inert storage depot for lipids
but is also an important endocrine organ that plays a key role in the integration of endocrine…

In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths 1 .
The World Health Organization has recommended artemisinin-based combination therapies (…

Background Insulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-binding
protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant …

OBJECTIVE—This study evaluated the ability of the incretin mimetic exenatide (exendin-4)
to improve glycemic control in patients with type 2 diabetes failing maximally effective doses …

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Background New treatments for type 2 diabetes mellitus are needed to retain insulin–glucose
coupling and lower the risk of weight gain and hypoglycaemia. We aimed to investigate …

TNFalpha is orverexpressed in the adipose tissue of obese rodents and humans, and is
associated with insulin resistance. To more closely link TNF expression with whole body insulin …

Context. —Heart failure is often preceded by isolated systolic hypertension, but the effectiveness
of antihypertensive treatment in preventing heart failure is not known. Objective. —To …