User profiles for R Shaw

Reuben Shaw

- Verified email at salk.edu - Cited by 60873

Ruth G. Shaw

- Verified email at umn.edu - Cited by 15977

Ras, PI (3) K and mTOR signalling controls tumour cell growth

RJ Shaw, LC Cantley - Nature, 2006 - nature.com
All eukaryotic cells coordinate cell growth with the availability of nutrients in their environment.
The mTOR protein kinase has emerged as a critical growth-control node, receiving …

Range shifts and adaptive responses to Quaternary climate change

MB Davis, RG Shaw - Science, 2001 - science.org
Tree taxa shifted latitude or elevation range in response to changes in Quaternary climate.
Because many modern trees display adaptive differentiation in relation to latitude or elevation…

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

MM Mihaylova, RJ Shaw - Nature cell biology, 2011 - nature.com
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated
protein kinase (AMPK), which is activated when intracellular ATP production …

Resveratrol improves health and survival of mice on a high-calorie diet

…, RG Spencer, EG Lakatta, D Le Couteur, RJ Shaw… - Nature, 2006 - nature.com
… was also improved for resveratrol-treated SD mice (R.deC. and KP, unpublished data). …
Author Contributions All experiments were designed and carried out by JAB, KJP, R.deC. …

Geometry from a time series

NH Packard, JP Crutchfield, JD Farmer, RS Shaw - Physical review letters, 1980 - APS
… See Shaw' for more complete discussions of the computation of the characteristic exponents
… In fact, we must have r «I/A, where I is the degree of accuracy with which one can specify a …

Additivity rules for the estimation of thermochemical properties

…, HE O'neal, AS Rodgers, R Shaw, R Walsh - Chemical …, 1969 - ACS Publications
The purpose of this review is to extend, as a result of the large increase in datasince 1958,
the group additivity scheme for estimation of thermochemical properties as originally pro-…

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

…, A Dillin, B Viollet, M Kundu, M Hansen, RJ Shaw - Science, 2011 - science.org
Adenosine monophosphate–activated protein kinase (AMPK) is a conserved sensor of
intracellular energy activated in response to low nutrient availability and environmental stress. In …

[PDF][PDF] AMPK phosphorylation of raptor mediates a metabolic checkpoint

…, A Mery, DS Vasquez, BE Turk, RJ Shaw - Molecular cell, 2008 - cell.com
AMPK is a highly conserved sensor of cellular energy status that is activated under conditions
of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and …

Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology

…, A Bunschoten, H Molhuizen, R Shaw… - Journal of clinical …, 1997 - Am Soc Microbiol
Widespread use of DNA restriction fragment length polymorphism (RFLP) to differentiate
strains of Mycobacterium tuberculosis to monitor the transmission of tuberculosis has been …

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy… - Science, 2005 - science.org
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase,
LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)–…