To better understand the distinct physiological roles played by progesterone and estrogen
receptors (PR amd ER) 4 as well as to study directly PR function in an in vivo context, a novel …

Ductal morphogenesis in the rodent mammary gland is characterized by the rapid
penetration of the stromal fat pad by the highly proliferative terminal endbud and sub-sequent …

Transforming growth factor alpha (TGFα) is a principal molecule in the normal and neoplastic
development of the mammary gland. Binding of TGFα to the epidermal growth factor …

… ability (43), although the properties defined in these in vitro assays do not always
correspond to their effects in vivo (RC Humphreys and JM Rosen, submitted for publication). …

The transcription factor Stat3 is activated through tyrosine phosphorylation by many
cytokines and is a fundamental mediator of their signals. In the mammary gland, Stat3 activity …

A human tumor cell’s ability to avoid the normal regulatory mechanisms of cell growth, division,
and death are the hallmarks of transformation and cancer. Numerous novel therapeutic …

Background This phase II study examined the efficacy of mapatumumab in combination with
paclitaxel and carboplatin in patients with non–small-cell lung cancer (NSCLC). Patients …

The mammary gland undergoes extensive tissue remodeling and cell death at the end of
lactation in a process known as involution. We present evidence that the prolactin-activated …

The Wnt gene family encodes a group of proteins probably involved in cell-cell communication
during several stages of vertebrate development. More than 10 members of this family …

Creation of ADCs by conjugating drug linkers and toxin payloads to available native lysines
or cysteines generates ADCs with highly variable drug to antibody loading and linker …