Apoptosis is characterized by a series of dramatic perturbations to the cellular architecture
that contribute not only to cell death, but also prepare cells for removal by phagocytes and …

Background Bioinformatics researchers are now confronted with analysis of ultra large-scale
data sets, a problem that will only increase at an alarming rate in coming years. Recent …

Aging cells accumulate damaged and misfolded proteins through a functional decline in their
protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the …

Characterization of the polypeptides present in bone-inductive protein extracts from bovine
bone has led to the cloning of seven regulatory molecules, six of which are distantly related …

Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells
toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-…

The index of refraction n of the many mammalian tissues is an important but somewhat
neglected optical constant. Archival and oral papers have quoted the use of values of n for tissue …

Infra-red spectra of twenty two metal-1:10-phenanthroline perchlorates together with spectra
of the free ligand, its hydrate and perchlorate salt have been obtained in the region between …

The ability to ensure proteostasis is critical for maintaining proper cell function and organismal
viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum …

Background Archaea represent a significant fraction of Earth's biodiversity, yet they remain
much less well understood than Bacteria. Gene surveys, a few metagenomic studies, and …

Examined the effects of nicotine administration and cigarette smoking on human performance
to clarify the role of such effects in controlling smoking. The results of 101 studies (129 …