User profiles for R. Fieldhouse

Robert Fieldhouse

Postdoctoral fellow, Memorial Sloan Kettering Cancer Center & Harvard Medical School
Verified email at cbio.mskcc.org
Cited by 2467

[PDF][PDF] Comprehensive molecular portraits of invasive lobular breast cancer

…, C Kandoth, R Bowlby, H Shen, S Hayat, R Fieldhouse… - Cell, 2015 - cell.com
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …

A History of Modern British Adult Education.

R Fieldhouse - 1996 - ERIC
The purpose of this book is: to set the historical development of British adult education in its
wider policy and ideological context; to examine its various forms and formulations; and to …

Needle in the haystack: structure-based toxin discovery

RJ Fieldhouse, AR Merrill - Trends in biochemical sciences, 2008 - cell.com
In the current data-rich era, making the leap from sequence data to knowledge is a task that
requires an elegant bioinformatics toolset to pinpoint pressing research questions. Therefore…

Prevalence estimates of predicted pathogenic COL4A3–COL4A5 variants in a population sequencing database and their implications for Alport syndrome

J Gibson, R Fieldhouse, MMY Chan… - Journal of the …, 2021 - journals.lww.com
Background The reported prevalence of Alport syndrome varies from one in 5000 to one in
53,000 individuals. This study estimated the frequencies of predicted pathogenic COL4A3–…

[HTML][HTML] Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae

R Jørgensen, AE Purdy, RJ Fieldhouse… - Journal of Biological …, 2008 - ASBMB
The ADP-ribosyltransferases are a class of enzymes that display activity in a variety of
bacterial pathogens responsible for causing diseases in plants and animals, including those …

Catalytic asymmetric epoxidation of aldehydes. Optimization, mechanism, and discovery of stereoelectronic control involving a combination of anomeric and Cieplak …

…, H Adams, RVH Jones, R Fieldhouse - Journal of the …, 1998 - ACS Publications
… The presence of the thioacetal moiety enables the R and R‘ groups to be easily varied in order
… d By analogy we have assumed that the same absolute configuration (R,R) was obtained. …

Catalytic cyclopropanation of electron deficient alkenes mediated by chiral and achiral sulfides: scope and limitations in reactions involving phenyldiazomethane and …

…, G Hynd, RVH Jones, R Fieldhouse… - Journal of the …, 2000 - pubs.rsc.org
Phenyldiazomethane reacts with electron deficient alkenes in the presence of catalytic amounts
of transition metal catalyst [Rh2(OAc)4 was better than Cu(acac)2] and catalytic amounts …

[HTML][HTML] A machine learning approach for hot-spot detection at protein-protein interfaces

R Melo, R Fieldhouse, A Melo, JDG Correia… - International journal of …, 2016 - mdpi.com
Understanding protein-protein interactions is a key challenge in biochemistry. In this work,
we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein …

[HTML][HTML] C3larvin toxin, an ADP-ribosyltransferase from Paenibacillus larvae

D Krska, R Ravulapalli, RJ Fieldhouse, MR Lugo… - Journal of Biological …, 2015 - ASBMB
C3larvin toxin was identified by a bioinformatic strategy as a putative mono-ADP-ribosyltransferase
and a possible virulence factor from Paenibacillus larvae, which is the causative …

[HTML][HTML] Cholera-and anthrax-like toxins are among several new ADP-ribosyltransferases

RJ Fieldhouse, Z Turgeon, D White… - PLoS computational …, 2010 - journals.plos.org
Chelt, a cholera-like toxin from Vibrio cholerae, and Certhrax, an anthrax-like toxin from
Bacillus cereus, are among six new bacterial protein toxins we identified and characterized …