… Hrs and some sorting nexins also associate with nascent phagosomes (OV Vieira and RJ
Botelho, unpublished work), but the precise function of these molecules remains to be …

Phosphoinositides play an important role in organelle identity by recruiting effector proteins
to the host membrane organelle, thus decorating that organelle with molecular identity. …

Cells of the innate immune system ingest and destroy invading microorganisms by initially
engulfing them into a specialized vacuole, known as the phagosome. The membrane of the …

… RJ Botelho is the recipient of a studentship from Natural Sciences and Engineering Council
of Canada. S. Grinstein is an International Scholar of the Howard Hughes Medical Institute …

… RJ Botelho. is a recipient of a graduate studentship from the Canadian Institutes of Health
Research. SM Brachmann is a recipient of a fellowship from Boehringer Ingelheim Funds. …

… naturally phagocytic through a receptor-mediated process (Botelho et al., 2000), inhibitors of
… CC Scott and RJ Botelho are recipients of graduate studentships from the CIHR. DA Knecht …

Background. Drug nonadherence to long-term medica tion is a common and poorly understood
problem in the elderly. A study was conducted to assess whether elderly patients would …

Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of macromolecular …

Lysosomes provide a niche for molecular digestion and are a convergence point for
endocytic trafficking, phagosome maturation and autophagy. Typically, lysosomes are small, …

The lipid kinase Fab1 governs yeast vacuole homeostasis by generating PtdIns(3,5)P 2 on
the vacuolar membrane. Recruitment of effector proteins by the phospholipid ensures precise …