Women who had previously given birth to one or more infants with a neural-tube defect (NTD)
were recruited into a trial of periconceptional multivitamin supplementation. 1 of 178 infants…

Serum folate, red cell folate, white blood cell vitamin C, riboflavin saturation index, and serum
vitamin A were determined during the first trimester of pregnancy in over 900 cases. For …

In accordance with a previous protocol, a second cohort of 254 mothers with a history of
previous neural tube defect (NTD) births was given a multivitamin supplement for not less than …

An earlier preliminary paper is expanded. Women who had given birth to one or more
infants with a neural tube defect were recruited into a trial of per conceptional vitamin …

For previous work see Abst. 2727, Vol. 35. In the main maternity centres of Liverpool in 1954,
98 women had babies with severe malformations; those were of the central nervous system …

Thalidomide: a brief history Thalidomide (alpha-phthalimido-glutarimide) was developed by
the German firm Chemie Grunenthal as an anticonvulsant drug. Early trials showed it to be …

Women who had had one or more previous neural tube defect (NTD) pregnancies, were not
pregnant and were considering a future pregnancy were asked to take Pregnavite Forte F (…

… RW SMITHELLS … Department of Paediatrics andChild Health, Leeds LS1 3ET RW
SMITHELLS, FRCP, Professor of Paediatrics and Child Health, University of Leeds … In an …

The incidence of congenital heart disease (CHD) in Liverpool from 1960 to 1969 inclusive
has been determined from the Liverpool Congenital Abnormalities Registry with a follow-up …

Of 111 children born in 1978-82 with congenital rubella infection, confirmed by the detection
of rubella specific IgM shortly after birth, 68 were reported to be hearing impaired when …