Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …

With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia
have not converged on findings that can be confidently used for precise experimental …

Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq)
affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq …

Glutamatergic, pyramidal-projection neurons are produced in the embryonic cerebral cortex
by a series of genetically programmed fate choices, implemented in large part by …

The developing cerebral cortex contains apical and basal types of neurogenic progenitor
cells. Here, we investigated the cellular properties and neurogenic output of basal progenitors, …

The adult mouse subependymal zone (SEZ) harbors neural stem cells that are thought to
exclusively generate GABAergic interneurons of the olfactory bulb. We examined the adult …

A protocol is described for sequencing the transcriptome of a cell nucleus. Nuclei are isolated
from specimens and sorted by FACS, cDNA libraries are constructed and RNA-seq is …

Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in
progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a …