Negative inotropic effects of cytokines on the heart mediated by nitric oxide

…, TD Jacob, SC Watkins, BG Hattler, RL Simmons - Science, 1992 - science.org
The direct effects of pro-inflammatory cytokines on the contractility of mammalian heart were
studied. Tumor necrosis factor α, interleukin-6, and interleukin-2 inhibited contractility of …

Virus‐associated hemophagocytic syndrome A benign histiocytic proliferation distinct from malignant histiocytosis

…, ME Nesbit, W Krivit, HH Balfour Jr, RL Simmons… - Cancer, 1979 - Wiley Online Library
Nineteen patients whose bone marrow smears showed histiocytic hyperplasia with prominent
hemophagocytosis were found to have a clinicopathologic syndrome associated with …

Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes

RD Nelson, PG Quie, RL Simmons - Journal of immunology, 1975 - journals.aai.org
A variety of methods have been devised for the study of spontaneous and directed cell migration.
Among these, the membrane filter method introduced by Boyden in 1962, with its more …

Increased incidence of malignancy during chronic renal failure

AJ Matas, CM Kjellstrand, RL Simmons, TJ Buselmeier… - The Lancet, 1975 - Elsevier
The incidence of cancer in 646 dialysis/ transplant patients before uræmia developed, during
the period of progressive uræmia, and post-transplantation was compared. 10 tumours (3 …

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

…, DK Nakayama, RL Simmons… - Proceedings of the …, 1993 - National Acad Sciences
Nitric oxide is a short-lived biologic mediator for diverse cell types. Synthesis of an inducible
nitric oxide synthase (NOS) in murine macrophages is stimulated by lipopolysaccharide (…

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

…, RA Shapiro, SC Wang, RL Simmons… - Proceedings of the …, 1993 - National Acad Sciences
Nitric oxide (NO.) is a short-lived mediator which can be induced in a variety of cell types
and produces many physiologic and metabolic changes in target cells. The inducible or high-…

Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications

…, CA Sirio, LM Farkas, KK Lee, RL Simmons - Annals of …, 2002 - journals.lww.com
Objective To review the epidemiology and characteristics of patients who died or underwent
colectomy secondary to fulminant Clostridium difficile colitis. Summary Background Data In …

Nitrogen oxide levels in patients after trauma and during sepsis.

…, TR Billiar, RD Curran, FB Cerra, RL Simmons… - Annals of …, 1991 - ncbi.nlm.nih.gov
The mediators responsible for maintenance of the hyperdynamic state and the low systemic
vascular resistance (SVR) observed in sepsis have not been elucidated. Nitric oxide (. N= O) …

Recurrence of idiopathic nephrotic syndrome after renal transplantation

JR Hoyer, L Raij, RL Vernier, RL Simmons, JS Najarian… - The Lancet, 1972 - Elsevier
Three patients with steroid-resistant idiopathic nephrotic syndrome were studied at onset
and during recurrent nephrotic syndrome after renal transplantation. Renal biopsies at the …

Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus

JC Kalff, WH Schraut, RL Simmons, AJ Bauer - Annals of surgery, 1998 - journals.lww.com
Background Data The common supposition is that more invasive operations are associated
with a more extensive ileus. The cellular mechanisms of postsurgical ileus remain elusive, …