Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

…, JK Howard, RJ Baker, SR Bloom, RI Lechler - Nature, 1998 - nature.com
Nutritional deprivation suppresses immune function 1 , 2 , 3 . The cloning of the obese gene
and identification of its protein product leptin 4 has provided fundamental insight into the …

[HTML][HTML] Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

…, F Perna, S Fontana, RI Lechler… - The Journal of …, 2002 - Am Soc Clin Investig
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and
their reversibility by leptin administration provide compelling evidence for the existence of …

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

…, L Brent, A Bushell, LA Turka, JA Bluestone, RI Lechler… - The Lancet, 2020 - thelancet.com
Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art
approach for reducing general immunosuppression in organ transplantation. We tested multiple …

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

…, AD Edwards, JD Isaacs, RI Lechler - Blood, The Journal …, 2001 - ashpublications.org
Despite thymic deletion of cells with specificity for self-antigens, autoreactive T cells are
readily detectable in the normal T-cell repertoire. In recent years, a population of CD4 + T cells …

[HTML][HTML] Identification of a B cell signature associated with renal transplant tolerance in humans

…, WH Marks, I Sanz, RI Lechler… - The Journal of …, 2010 - Am Soc Clin Investig
Establishing long-term allograft acceptance without the requirement for continuous
immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal …

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells

…, D Golshayan, E Cernuda-Morollón, R Wait, RI Lechler - Blood, 2007 - ashpublications.org
The naturally occurring population of dedicated regulatory T cells that coexpress CD4 and
CD25 is known to play a key role in the maintenance of peripheral T-cell tolerance; however, …

[HTML][HTML] Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

…, MA Ghatei, MA Ritter, RI Lechler… - The Journal of …, 1999 - Am Soc Clin Investig
Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours’ starvation of normal
mice reduced the total thymocyte count to 13% of that observed in freely fed controls, …

[HTML][HTML] Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

…, MP Hernandez-Fuentes, RI Lechler - The Journal of …, 2010 - Am Soc Clin Investig
Identifying transplant recipients in whom immunological tolerance is established or is developing
would allow an individually tailored approach to their posttransplantation management. …

Organ transplantation—how much of the promise has been realized?

RI Lechler, M Sykes, AW Thomson, LA Turka - Nature medicine, 2005 - nature.com
Since the introduction of organ transplantation into medical practice, progress and optimism
have been abundant. Improvements in immunosuppressive drugs and ancillary care have …

A novel pathway of alloantigen presentation by dendritic cells

…, MJ James, FM Marelli-Berg, RI Lechler - The Journal of …, 2004 - journals.aai.org
In the context of transplantation, dendritic cells (DCs) can sensitize alloreactive T cells via
two pathways. The direct pathway is initiated by donor DCs presenting intact donor MHC …