Arterial pressure regulation: overriding dominance of the kidneys in long-term regulation and in hypertension

…, KW Scheel, RD Manning, RA Norman - The American journal of …, 1972 - Elsevier
The body is endowed with many different arterial pressure regulating mechanisms, some of
which operate rapidly, some slowly; some of which operate at low pressure ranges, some at …

Systems analysis of arterial pressure regulation and hypertension

…, AW Cowley, JF Liard, RA Norman… - Annals of biomedical …, 1972 - Springer
In this paper we have presented briefly three different aspects of arterial pressure regulation
and of the hypertension problem: (1) the basic principles of arterial pressure control, …

Continuous monitoring of arterial pressure indicates sinoaortic denervated rats are not hypertensive.

RA Norman Jr, TG Coleman, AC Dent - Hypertension, 1981 - Am Heart Assoc
The mean arterial pressure (MAP) of nine sinoaortic denervated (SAD) and eight control
rats housed in standard-sized metabolic cages was determined continuously via aortic …

Subpressor angiotensin infusion, renal sodium handling, and salt-induced hypertension in the dog.

…, AW Cowley Jr, TG Coleman, RA Norman Jr… - Circulation …, 1978 - Am Heart Assoc
We studied the combined effect of subpressor amounts of angiotensin and long-term sodium
chloride infusion on arterial pressure in 16 dogs for periods of 2--8 weeks. In dogs receiving …

Role of the renal nerves in one-kidney, one clip hypertension in rats.

RA Norman Jr, WR Murphy, DJ Dzielak, AA Khraibi… - …, 1984 - Am Heart Assoc
The effects of renal denervation on the onset and maintenance of one-kidney, one clip Goldblatt
(1K1C) hypertension were determined. Renal denervation was performed at the time of …

Chronic immunosuppression attenuates hypertension in Okamoto spontaneously hypertensive rats

AA Khraibi, RA Norman Jr… - American Journal of …, 1984 - journals.physiology.org
Recent evidence suggests that hypertension in the Okamoto spontaneously hypertensive
rat (SHR) may be the result of an autoimmune disorder. To test this hypothesis SHRs were …

The pathogenic role of the kidney

…, RD Manning Jr, JE Hall, RA Norman Jr… - Journal of …, 1984 - journals.lww.com
The discussions of this article suggest that the pressure natriuresis mechanism of the kidneys
is the most important of all long-term regulators of arterial pressure. This is especially so …

Brief Reviews: A Systems Analysis Approach to Understanding Long-Range Arterial Blood Pressure Control and Hypertension

…, RD MANNING Jr, RA NORMAN Jr… - Circulation …, 1974 - Am Heart Assoc
• The use of systems analysis as an experimental tool for solving complex physiological
problems is not new. Actually, systems analysis is merely the logical analysis of how systems …

Immune system dysfunction contributes to the aetiology of spontaneous hypertension

RA Norman Jr, DJ Dzielak, KL Bost… - Journal of …, 1985 - journals.lww.com
Spontaneously hypertensive rats (SHRs) have a depressed T lymphocyte system, especially
a reduced activity of the suppressor T cells, and it has been postulated that an auto-immune …

Mechanisms of partial renal infarct hypertension

RA Norman Jr, PG Galloway, DJ Dzielak… - Journal of …, 1988 - journals.lww.com
Contributions of both the renin-angiotensin and immune systems to the aetiology of renal
infarct hypertension were examined in Sprague-Dawley rats. Partial renal infarction was …