After 4 years of debate, a decision has been made. The attenuated psychosis syndrome (APS)
will not be a coded diagnosis in the Diagnostic and Statistical Manual of Mental Disorders …

Background Implementation fidelity refers to the degree to which an intervention or programme
is delivered as intended. Only by understanding and measuring whether an intervention …

Context During the past 2 decades, a major transition in the clinical characterization of psychotic
disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has …

Background The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral
antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …

I discuss the production of low rank smoothers for d ≥ 1 dimensional data, which can be
fitted by regression or penalized regression methods. The smoothers are constructed by a …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

The first edition of this book has established itself as one of the leading references on
generalized additive models (GAMs), and the only book on the topic to be introductory in nature …

… robustness on the earlier method of Wood for prediction error criteria based smoothness …
Negative w i provide the second reason that the Wood (2008) method cannot be extended …