Objectives. To identify the instruments that have been used to measure health-related quality
of life (HRQOL) in gout and assess their clinimetric properties, determine the distribution of …

Background Hyperuricaemia, the biochemical precursor to gout, has been shown to be an
independent risk factor for mortality from cardiovascular disease (CVD), although studies …

… Samantha Hider has no conflicts of interest that are directly relevant to the content of this
study. Professor David L. Scott has received fees for consulting and giving educational lectures …

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …

Objectives. Depression is common in RA and may be influenced by both disease activity
and severity. The aims of this study were to investigate the prevalence of depression in RA …

We investigated the effect of single-nucleotide polymorphisms (SNPs) spanning 10
methotrexate (MTX) pathway genes, namely AMPD1, ATIC, DHFR, FPGS, GGH, ITPA, MTHFD1, …

Objectives To determine whether gout increases risk of incident coronary heart disease (CHD),
cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of …

Objectives: Low back pain (LBP) with leg pain, especially with findings of nerve root
involvement, is considered as a poor prognostic indicator although it seems to have a favorable …

Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not
universally effective and up to one-third of patients fail to respond to treatment, either because …

Association of two key variants mapping to the MTHFR gene (C677T (rs1801133) and
A1298C (rs1801131)) with response to methotrexate (MTX) remains controversial. We …