Topographical cues, independent of biochemistry, generated by the extracellular matrix may
have significant effects upon cellular behavior. Studies have documented that substratum …

Integrins are α/β heterodimeric adhesion glycoprotein receptors that regulate a wide variety
of dynamic cellular processes such as cell migration, phagocytosis, and growth and …

Integrins are a large family of molecules that are central regulators in multicellular biology.
They orchestrate cell–cell and cell–extracellular matrix (ECM) adhesive interactions from …

The structural basis for the divalent cation–dependent binding of heterodimeric αβ integrins
to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. …

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell and
cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the …

The α V β 3 integrin receptor plays an important role in human tumor metastasis and tumor-induced
angiogenesis. The in vivo inhibition of this receptor by antibodies or by cyclic …

The α V β 3 integrin is implicated in human tumor metastasis and in angiogenesis. The design
of low-molecular-mass α V β 3 antagonists by “spatial screening” led to the highly active …

The α v β 3 integrin is an important cell adhesion receptor involved in tumor-induced
angiogenesis and tumor metastasis. Here we describe the 18 F-labeling of the RGD-containing …

The α V β 3 integrin plays an important role in metastasis and tumor-induced angiogenesis.
Targeting with radiolabeled ligands of the α V β 3 integrin may provide information about the …

This paper quantitatively defines the nanoscale topography of the basement membrane
underlying the anterior corneal epithelium of the macaque. Excised corneal buttons from …