User profiles for Saran Shantikumar

Saran Shantikumar

University of Warwick
Verified email at warwick.ac.uk
Cited by 2484

Role of microRNAs in diabetes and its cardiovascular complications

S Shantikumar, A Caporali… - Cardiovascular …, 2012 - academic.oup.com
Diabetes is the most common metabolic disorder and is recognized as one of the most important
health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding small …

[HTML][HTML] Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis

RW Major, MRI Cheng, RA Grant, S Shantikumar, G Xu… - PloS one, 2018 - journals.plos.org
Background and objectives Chronic kidney disease (CKD) is a global health burden and is
independently associated with increased cardiovascular disease risk. Assessment of …

Canagliflozin, dapagliflozin and empagliflozin monotherapy for treating type 2 diabetes: systematic review and economic evaluation

…, BK Tan, A Clegg, S Shantikumar… - Health Technology …, 2017 - wrap.warwick.ac.uk
Background Most people with type 2 diabetes are overweight, so initial treatment is aimed
at reducing weight and increasing physical activity. Even modest weight loss can improve …

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with …

…, O Fortunato, A Caporali, S Shantikumar… - Circulation …, 2013 - Am Heart Assoc
Rationale: Circulating proangiogenic cells (PACs) support postischemic neovascularization.
Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via …

[HTML][HTML] Human pericardial fluid contains exosomes enriched with cardiovascular-expressed microRNAs and promotes therapeutic angiogenesis

C Beltrami, M Besnier, S Shantikumar, AIU Shearn… - Molecular Therapy, 2017 - cell.com
The pericardial fluid (PF) is contained in the pericardial sac surrounding the heart.
MicroRNA (miRNA) exchange via exosomes (endogenous nanoparticles) contributes to cell-to-cell …

[HTML][HTML] Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: an example of exosome …

…, A Mumford, A Clayton, M Gurney, S Shantikumar… - PLoS one, 2016 - journals.plos.org
Introduction Exosome nanoparticles carry a composite cargo, including microRNAs (miRs).
Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of …

[HTML][HTML] p75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte–endothelial crosstalk in diabetes after limb ischaemia

…, M Meloni, A Nailor, T Mitić, S Shantikumar… - Nature …, 2015 - nature.com
The communication between vascular endothelial cells (ECs) and pericytes in the microvasculature
is fundamental for vascular growth and homeostasis; however, these processes are …

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester …

…, T Mitić, AM Posadino, S Shantikumar… - … , and vascular biology, 2015 - Am Heart Assoc
Objective— Gestational diabetes mellitus (GDM) produces fetal hyperglycemia with increased
lifelong risks for the exposed offspring of cardiovascular and other diseases. Epigenetic …

From lecture theatre to portable media: students' perceptions of an enhanced podcast for revision

S Shantikumar - Medical Teacher, 2009 - Taylor & Francis
Background: Podcasting is a novel medium used worldwide for information transfer and
entertainment, available in both audio-only and enhanced audiovisual formats. Aims: We aim to …

Systematic versus opportunistic risk assessment for the primary prevention of cardiovascular disease

M Dyakova, S Shantikumar, JL Colquitt… - Cochrane Database …, 2016 - cochranelibrary.com
Background Screening programmes can potentially identify people at high cardiovascular
risk and reduce cardiovascular disease (CVD) morbidity and mortality. However, there is …