The UK Medical Research Council’s widely used guidance for developing and evaluating
complex interventions has been replaced by a new framework, commissioned jointly by the …

Background The Medical Research Council published the second edition of its framework
in 2006 on developing and evaluating complex interventions. Since then, there have been …

Objective To evaluate the effectiveness and costs of a multifaceted flexible educational
programme aimed at reducing antibiotic dispensing at the practice level in primary care. Design …

Background There is increasing interest in digital technologies to help improve children and
young people’s mental health, and the evidence for the effectiveness for these approaches …

Though a link between sexual victimization and alcohol use has been well documented, the
mechanisms underlying this relationship remain unclear. The current study used path …

BackgroundBipolar disorder is complex and can be difficult to diagnose. It is often misdiagnosed
as recurrent major depressive disorder.AimsWe had three main aims. To estimate the …

Objectives: Interventions aimed at enhancing the quality of antibiotic prescribing often highlight
the threat of antimicrobial resistance. Although most antibiotics are prescribed by general …

Background Evaluations of complex interventions in public health are frequently undermined
by problems that can be identified before the effectiveness study stage. Exploratory studies, …

Objectives To evaluate the effect of training primary care health professionals in behaviour
change counselling on the proportion of patients self reporting change in four risk behaviours …

Background Otitis media with effusion (OME) is common and may cause hearing loss with
associated developmental delay. Treatment remains controversial. Objectives To examine the …