This review describes normal and abnormal wound healing, the latter characterized by
excessive fibrosis and scarring, which for lung can result in morbidity and sometimes mortality. …

Transforming growth factor beta 1 (TGF‐β1) plays a key role in connective tissue remodeling,
scarring, and fibrosis. The effects of mechanical forces on TGF‐β1 and collagen deposition …

The Src kinase controls aspects of cell biology and its activity is regulated by intramolecular
structural changes induced by protein interactions and tyrosine phosphorylation. Recent …

The smooth muscle myosin heavy chain (SM-MHC) gene encodes a major contractile
protein whose expression exclusively marks the smooth muscle cell (SMC) lineage. To better …

The R403Q mutation in the β-myosin heavy chain (MHC) was the first mutation to be linked
to familial hypertrophic cardiomyopathy (FHC), a primary disease of heart muscle. The initial …

Protein-S-glutathionylation is a post-translational modification involving the conjugation of
glutathione to protein thiols, which can modulate the activity and structure of key cellular …

Glutathione (GSH) is a critical component of the cellular redox system that combats oxidative
stress. The glutamate-cystine antiporter, system x C − , is a key player in GSH synthesis that …

Smooth muscle myosin heavy chain (SMHC) isoforms, SM1 and SM2, are the products of
alternative splicing from a single gene (P. Babij and M. Periasamy. J. Mol. Biol. 210: 673-679, …

A series of serotonergic agents were assessed for their ability to antagonize isolation-induced
aggression and their activity to disrupt performance in the rotorod motor coordination test. …

Clones were derived by dilute plating from cultured aortic smooth muscle cells of 12-day-old
rats. Clones Pup I to III resemble uncloned smooth muscle cultures from aortas of rat pups …