Measuring depression severity in general practice: discriminatory performance of the PHQ-9, HADS-D, and BDI-II

…, K Lawton, K Mitchell, S Sharma, S Shivaprasad… - British Journal of …, 2011 - bjgp.org
Background The UK Quality and Outcomes Framework (QOF) rewards practices for measuring
symptom severity in patients with depression, but the endorsed scales have not been …

Low-dose doxorubicin with carotenoids selectively alters redox status and upregulates oxidative stress-mediated apoptosis in breast cancer cells

K Vijay, PRR Sowmya, BP Arathi, S Shilpa… - Food and chemical …, 2018 - Elsevier
The combination of carotenoids and doxorubicin (DOX) selectively alters oxidative stress-mediated
apoptosis in breast cancer cells. Primarily, cytotoxic efficiency of carotenoids (β-…

Psychometric properties of the Quick Inventory of Depressive Symptomatology (QIDS-SR) in UK primary care

…, S Hay, K Mitchell, S Sharma, S Shivaprasad… - Journal of psychiatric …, 2013 - Elsevier
It is widely believed that severity of depressive disorder should guide treatment selection
and many guidelines emphasise this factor. The Quick Inventory of Depressive …

Fractionation and Characterization of Lycopene-Oxidation Products by LC-MS/MS (ESI)+: Elucidation of the Chemopreventative Potency of Oxidized Lycopene in …

…, GC Kuriakose, S Shilpa… - Journal of agricultural …, 2018 - ACS Publications
Lycopene (LYC) has been correlated with the reduction of certain cancers and chronic diseases.
However, the existence and biofunctionality of degraded, oxidized, and biotransformed …

Fabrication of chitosan nanoparticles with phosphatidylcholine for improved sustain release, basolateral secretion, and transport of lutein in Caco-2 cells

HJ Shwetha, S Shilpa, MB Mukherjee… - International Journal of …, 2020 - Elsevier
Biopolymers-based nanoparticles delivery emerged alternatively to improve nutraceuticals
and drug bioavailability. The intestinal physiology suggested a prerequisite of lipid moiety for …

Factors affecting bioaccessibility and bio-efficacy of carotenoids

S Shilpa, HJ Shwetha, M Raju… - Carotenoids: Properties …, 2020 - Elsevier
Carotenoids are natural pigments, and recognized as vital micronutrients associated with
human health. Epidemiological studies have been shown that consumption of carotenoid-rich …

Turmeric, red pepper, and black pepper affect carotenoids solubilized micelles properties and bioaccessibility: Capsaicin/piperine improves and curcumin inhibits …

S Shilpa, HJ Shwetha, MK Perumal… - Journal of Food …, 2021 - Wiley Online Library
This study aimed to evaluate the role of spices/spice active principles on physical,
biochemical, and molecular targets of bioaccessibility/bioavailability. Carotenoids‐rich micellar …

Zein-Alginate-Phosphatidylcholine Nanocomplex Efficiently Delivers Lycopene and Lutein over Dietary-Derived Carotenoid Mixed Micelles in Caco-2 Cells

…, R Ambedkar, S Shivaprasad… - Journal of Agricultural …, 2022 - ACS Publications
This study evaluated the potency of zein-alginate-phosphatidylcholine nanoparticles (NPs)
on bioaccessibility/intestinal uptake of encapsulated lycopene (LY) and lutein (LT) versus …

Biofortification of Carotenoids in Agricultural and Horticultural Crops: A Promising Strategy to Target Vitamin A Malnutrition

HJ Shwetha, S Shilpa, BP Arathi, M Raju… - … of Edible Plants, 2020 - Wiley Online Library
This chapter highlights the techniques, methods, and various approaches of biofortification
of provitamin and non‐provitamin A carotenoids in agricultural and horticultural crops. It …

[PDF][PDF] Spice active ingredients affect the micellization, permeation and bioavailability of structurally different carotenoids in human intestinal epithelial Caco-2 cells.

S Shilpa, R Ambedkar, HJ Shwetha… - The Indian Journal of …, 2021 - researchgate.net
The study evaluated the influence of active spice ingredients on the bioaccessibility and
bioavailability of different carotenoids at the enterocyte level. Briefly, carotenoids solubilized …