Insect wings are complex structures that deform dramatically in flight. We analyzed the
aerodynamic consequences of wing deformation in locusts using a three-dimensional …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure, …

Autophagy is the engulfment of cytosol and organelles by double-membrane vesicles termed
autophagosomes. Autophagosome formation is known to require phosphatidylinositol 3-…

The fluorescence of pyrene-labelled actin is much higher after polymerization. We have
characterized in detail the polymerization properties of pyrene actin and report that native and …

Cardiac failure occurs when the heart fails to adapt to chronic stresses. Reactive oxygen
species (ROS)-dependent signaling is implicated in cardiac stress responses, but the role of …

Objective To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin
I assay and sex specific diagnostic thresholds in men and women with suspected acute …

Context Although troponin assays have become increasingly more sensitive, it is unclear
whether further reductions in the threshold of detection for plasma troponin concentrations will …

Objective— Increased reactive oxygen species (ROS) production is involved in the
pathophysiology of endothelial dysfunction. NADPH oxidase-4 (Nox4) is a ROS-generating enzyme …

Background High-sensitivity cardiac troponin assays permit use of lower thresholds for the
diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown. …

Autophagosome formation requires sequential translocation of autophagy-specific proteins
to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest …