Background Few randomised controlled trials (RCTs) have evaluated the different recalling
approaches for enhancing adherence to faecal immunochemical test (FIT)-based screening. …

Methods| We conducted a prospective randomized parallel group study, with the setting
previously described. 4 The trial was registered on Clinicaltrials. gov (NCT02815436). …

Background Despite the proven effectiveness of colorectal cancer (CRC) screening on reduction
of CRC mortality, the uptake of CRC screening remains low. Participation rate is one of …

Impaired angiogenesis in ischemic tissue is a hallmark of diabetes. Thioredoxin-interacting
protein (TXNIP) is an exquisitely glucose-sensitive gene that is overexpressed in diabetes. …

There is a progressive impairment of vascular repair mechanisms with advancing age
concomitant with a steady decline in circulating androgen levels in men. Emerging evidence …

Fenofibrate, a peroxisome proliferator–activated receptor α (PPARα) agonist, reduces lower
limb amputations in patients with type 2 diabetes. The mechanism is, however, unknown. In …

Objective Obstructive sleep apnoea (OSA) is characterised by reoccurring apnoeas and
hypopneas, causing repetitive hypoxia and reoxygenation, and is associated with endothelial …

Background Endothelial progenitor cells (EPCs) are implicated in protection against vascular
disease. However, studies using angiography alone have reported conflicting results when …

Endothelial progenitor cells (EPCs) play a key role in neovascularization and have been
linked to improved cardiovascular outcomes. Although there is a well-established inverse …

The IGFBPs are a family of homologous proteins that have co-evolved with the IGFs and that
confer upon the IGF regulatory system both functional and tissue specificity. IGFBPs are not …