Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory
diseases, inhibit the expression of many inflammatory mediators. They can also induce the …

The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti-inflammatory …

Background Chlamydia is the most common sexually transmitted bacterial infection
worldwide. National screening programmes and antibiotic treatment have failed to decrease …

Objectives To establish if changes in Th1/Th17 cell populations previously reported in
experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour …

Objectives To evaluate the efficacy and safety of an oral phosphodiesterase 4 inhibitor,
apremilast, in treatment of ankylosing spondylitis (AS) by monitoring symptoms and signs in a …

Trial design We present a study protocol for a multi-centre, randomised, double-blind,
parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and …

The human body consists of millions of commensal bacteria (the microbiome), with the
intestinal tract being the most prevalent site of colonization. This colonization process begins at …

In recent years it has become increasingly recognised that immunogenicity of vaccines can
vary significantly between individuals, with age, comorbidities and medication use being …

In late 2019, a hematologist from the University of North Carolina received a phone call from
space—it was a request to evaluate an astronaut on the International Space Station who …

Objective. To assess the value of quantitative vascular imaging by power Doppler US (PDUS)
as a tool that can be used to stratify patient risk of joint damage in early seropositive RA …