Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid
levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is the sum …

This trusted textbook returns in its 4th edition with even more exercises to help consolidate
understanding-and a companion website featuring additional materials, including a solutions …

This book covers the practical and theoretical aspects necessary to design modern highspeed
digital systems at the platform level. The book walks the reader through every required …

This second edition has been thoroughly updated to include recent advances and developments
in the field of fermentation technology, focusing on industrial applications. The book …

Background Systemic lupus erythematosus is a heterogeneous autoimmune disease that is
associated with B-cell hyperactivity, autoantibodies, and increased concentrations of B-…

Differences in phenological responses to climate change among species can desynchronise
ecological interactions and thereby threaten ecosystem function. To assess these threats, …

Marine reserves are a promising tool for fisheries management and conservation of biodiversity,
but they are not a panacea for fisheries management problems. For fisheries that target …

Background Remission and radiographic non-progression are goals in the treatment of early
rheumatoid arthritis. The aim of the combination of methotrexate and etanercept in active …

The effects of towed bottom‐fishing gear on benthic communities is the subject of heated
debate, but the generality of trawl effects with respect to gear and habitat types is poorly …

Takayasu arteritis is a chronic inflammatory arteriopathy of unknown etiology affecting large
vessels, particularly the aorta and its main branches, and to a lesser extent the pulmonary …