The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution
FA Rey, FX Heinz, C Mandl, C Kunz, SC Harrison - Nature, 1995 - nature.com
The crystallographically determined structure of a soluble fragment from the major envelope
protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a …
protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a …
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor,
angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on …
angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on …
The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases
…, M Charlton, K Cusi, M Rinella, SA Harrison… - Hepatology, 2018 - journals.lww.com
This guidance provides a data‐supported approach to the diagnostic, therapeutic, and
preventive aspects of nonalcoholic fatty liver disease (NAFLD) care. A “Guidance” document is …
preventive aspects of nonalcoholic fatty liver disease (NAFLD) care. A “Guidance” document is …
MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population,
and has no approved drug therapy. Although pharmacotherapies are in development, …
and has no approved drug therapy. Although pharmacotherapies are in development, …
[BOOK][B] Generic enrichment in Vergil and Horace
SJ Harrison - 2007 - books.google.com
SJ Harrison sets out to sketch one answer to a key question in Latin literary history: why did
the period c. 39-19 BC in Rome produce such a rich range of complex poetical texts, above …
the period c. 39-19 BC in Rome produce such a rich range of complex poetical texts, above …
X-ray structure of a protein-conducting channel
…, I Collinson, Y Modis, E Hartmann, SC Harrison… - Nature, 2004 - nature.com
A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms
a protein-conducting channel, allowing polypeptides to be transferred across or integrated …
a protein-conducting channel, allowing polypeptides to be transferred across or integrated …
Structure of the dengue virus envelope protein after membrane fusion
Y Modis, S Ogata, D Clements, SC Harrison - Nature, 2004 - nature.com
Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor
and responds by conformational rearrangement to the reduced pH of an endosome. The …
and responds by conformational rearrangement to the reduced pH of an endosome. The …
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α helices: crystal structure of the protein-DNA complex
The yeast transcriptional activator GCN4 is 1 of over 30 identified eukaryotic proteins
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined the …
containing the basic region leucine zipper (bZIP) DNA-binding motif. We have determined the …
[HTML][HTML] Structure of an IκBα/NF-κB complex
MD Jacobs, SC Harrison - Cell, 1998 - cell.com
The inhibitory protein, IκBα, sequesters the transcription factor, NF-κB, as an inactive complex
in the cytoplasm. The structure of the IκBα ankyrin repeat domain, bound to a partially …
in the cytoplasm. The structure of the IκBα ankyrin repeat domain, bound to a partially …
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
Z Songyang, KL Carraway III, MJ Eck, SC Harrison… - Nature, 1995 - nature.com
HOW do distinct protein-tyrosine kinases activate specific downstream events? Src-homology-2
(SH2) domains on tyrosine kinases or targets of tyrosine kinases recognize …
(SH2) domains on tyrosine kinases or targets of tyrosine kinases recognize …