Opportunistic screening versus usual care for diagnosing atrial fibrillation in general practice: a cluster randomised controlled trial

F Kaasenbrood, M Hollander, SHM de Bruijn… - British Journal of …, 2020 - bjgp.org
Background Atrial fibrillation (AF) increases the risk of stroke, heart failure, and all-cause
mortality. AF may be asymptomatic and therefore remain undiagnosed. Devices such as single-…

Application of the ugi multicomponent reaction in the synthesis of reactivators of nerve agent inhibited acetylcholinesterase

…, DPW Alkema, T Wille, HM de Bruijn - Journal of Medicinal …, 2017 - ACS Publications
Recently, a new class of reactivators of chemical warfare agent inhibited acetylcholinesterase
(AChE) with promising in vitro potential was developed by the covalent linkage of an …

[PDF][PDF] A comprehensive pan-cancer molecular study of gynecologic and breast cancers

…, J Armenia, D Chakravarty, WK Chatila, I de Bruijn… - Cancer cell, 2018 - cell.com
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …

[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer

…, J Armenia, D Chakravarty, WK Chatila, I de Bruijn… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

[PDF][PDF] Genomic and molecular landscape of DNA damage repair deficiency across the cancer genome atlas

…, J Armenia, D Chakravarty, WK Chatila, I de Bruijn… - Cell reports, 2018 - cell.com
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view of …

Comparative Sequence Analysis of the Symbiosis Island of Mesorhizobium loti Strain R7A

…, JE Weaver, RJ Webby, FJ De Bruijn… - Journal of …, 2002 - Am Soc Microbiol
The Mesorhizobium loti strain R7A symbiosis island is a 502-kb chromosomally integrated
element which transfers to nonsymbiotic mesorhizobia in the environment, converting them to …

[PDF][PDF] The cancer genome atlas comprehensive molecular characterization of renal cell carcinoma

…, J Armenia, D Chakravarty, WK Chatila, I de Bruijn… - Cell reports, 2018 - cell.com
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers
with different genetic drivers, clinical courses, and therapeutic responses. The current …

[PDF][PDF] Genomic and functional approaches to understanding cancer aneuploidy

…, J Armenia, D Chakravarty, WK Chatila, I de Bruijn… - Cancer cell, 2018 - cell.com
Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal
characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, …

[PDF][PDF] Uncovering Zimbabwe's debt

…, O Brynildsen, P Bond, K Rehbein, K de Bruijn… - Jubilee Debt …, 2011 - erlassjahr.de
Eurodad works to push for policies that support pro-poor and democratically-defined sustainable
development strategies. We support the empowerment of Southern people to chart their …

[PDF][PDF] Pathogenic germline variants in 10,389 adult cancers

…, J Armenia, D Chakravarty, WK Chatila, I de Bruijn… - Cell, 2018 - cell.com
We conducted the largest investigation of predisposition variants in cancer to date, discovering
853 pathogenic or likely pathogenic variants in 8% of 10,389 cases from 33 cancer types. …