Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state
…, K Murray, CL Hoad, SE Pritchard… - Molecular …, 2014 - ACS Publications
The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly
dependent upon the volumes and distribution of gastric and small intestinal water. However…
dependent upon the volumes and distribution of gastric and small intestinal water. However…
Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
BACKGROUND & AIMS: Postprandial symptoms are common in patients with irritable
bowel syndrome with diarrhea (IBS-D) and could be diet related. We studied postprandial …
bowel syndrome with diarrhea (IBS-D) and could be diet related. We studied postprandial …
[HTML][HTML] Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK …
Background Neoadjuvant chemotherapy before surgery improves survival compared with
surgery alone for patients with oesophageal cancer. The OE05 trial assessed whether …
surgery alone for patients with oesophageal cancer. The OE05 trial assessed whether …
Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea‐predominant irritable bowel syndrome measured using serial MRI
SE Pritchard, L Marciani, KC Garsed… - …, 2014 - Wiley Online Library
Background Previous assessments of colon morphology have relied on tests which were
either invasive or used ionizing radiation. We aimed to measure regional volumes of the …
either invasive or used ionizing radiation. We aimed to measure regional volumes of the …
Neoadjuvant chemotherapy for resectable oesophageal and junctional adenocarcinoma: Results from the UK Medical Research Council randomised OEO5 trial …
…, J Thompson, R Krysztopik, FY Coxon, S Pritchard… - 2015 - ascopubs.org
4002 Background: Neoadjuvant chemotherapy (2 cycles cisplatin/5 fluorouracil) (CF)
followed by surgery is a standard of care for locally advanced oesophageal cancer. We …
followed by surgery is a standard of care for locally advanced oesophageal cancer. We …
[HTML][HTML] Preventing gastric sieving by blending a solid/water meal enhances satiation in healthy humans
Separation of solids and liquids within the stomach allows faster gastric emptying of liquids
compared with solids, a phenomenon known as sieving. We tested the hypothesis that …
compared with solids, a phenomenon known as sieving. We tested the hypothesis that …
Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro‐oesophageal junction cancers
…, CM West, RD Page, IM Welch, SA Pritchard - …, 2010 - Wiley Online Library
Brown M, Sillah K, Griffiths EA, Swindell R, West CM, Page RD, Welch IM & Pritchard SA (2010)
Histopathology 56, 893–899 Tumour budding and a low host inflammatory response are …
Histopathology 56, 893–899 Tumour budding and a low host inflammatory response are …
Tumor length as a prognostic factor in esophageal malignancy: univariate and multivariate survival analyses
…, Z Brummell, G Gorthi, SA Pritchard… - Journal of surgical …, 2006 - Wiley Online Library
Background and Objectives Gastrointestinal specialists generally feel that long esophageal
tumors carry a worse prognosis and are likely to be more advanced than shorter lesions. Our …
tumors carry a worse prognosis and are likely to be more advanced than shorter lesions. Our …
[HTML][HTML] Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel …
L Marciani, SE Pritchard, C Hellier-Woods… - European journal of …, 2013 - nature.com
Results: The MRI intragastric appearance of the two meals was markedly different. The WMB
meal formed a homogeneous dark bolus with brighter liquid signal surrounding it. The RP …
meal formed a homogeneous dark bolus with brighter liquid signal surrounding it. The RP …
Nuclear organization and chromatin dynamics–Sp1, Sp3 and histone deacetylases
…, KL Dunn, JM Sun, HY Chen, J Yu, S Pritchard… - Advances in enzyme …, 2008 - Elsevier
Regulation of gene expression involves the coordinated activities and interplay between
chromatin remodeling factors and transcription factor recruitment. Histone acetyltransferases, …
chromatin remodeling factors and transcription factor recruitment. Histone acetyltransferases, …