Inhibition of growth and sensitization to cisplatin‐mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents

…, D Fong, KJ Soprano, WF Holmes… - Journal of cellular …, 2003 - Wiley Online Library
The polyphenolic compounds curcumin and quercetin increased sensitivity of ovarian cancer
cells (CAOV3 and SKOV3) to cisplatin. The effect was obtained when the compounds were …

Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines

WF Holmes, DR Soprano… - Journal of cellular …, 2004 - Wiley Online Library
Apoptosis is also known as programmed cell death. Apoptosis plays an essential role in
maintaining normal tissue and cell physiology in multicellular organisms. Clearance of aberrant …

Retinoids and ovarian cancer

D Zhang, WF Holmes, S Wu… - Journal of cellular …, 2000 - Wiley Online Library
… not alter induction of apoptosis by 4-HPR (Holmes and Soprano, unpublished observations).
WF Holmes was funded in part by a training grant from the National Institutes of Health to …

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

…, HL Olsen, M Høy, CF Gotfredsen, WF Holmes… - Pflügers Archiv, 1999 - Springer
We have monitored whole-cell and single channel ATP-sensitive K + (K ATP ) currents in
isolated rat glucagon-secreting pancreatic A-cells. Tolbutamide produced a concentration-…

Induction of stem cell gene expression in adult human fibroblasts without transgenes

RL Page, S Ambady, WF Holmes, L Vilner… - Cloning and stem …, 2009 - liebertpub.com
Reprogramming of differentiated somatic cells into induced pluripotent stem (iPS) cells has
potential for derivation of patient-specific cells for therapy as well as for development of …

Migraine-related disability: impact and implications for sufferers' lives and clinical issues

WF Holmes, EA MacGregor, D Dodick - Neurology, 2001 - AAN Enterprises
Article abstract Migraine is a common, debilitating disorder that imposes a large personal
burden on sufferers and high economic costs on society. Sufferers have a significant level of …

Reducing reconsultations for acute lower respiratory tract illness with an information leaflet: a randomized controlled study of patients in primary care.

JT Macfarlane, WF Holmes, RM Macfarlane - British Journal of General …, 1997 - bjgp.org
BACKGROUND: General practitioners (GPs) prescribe antibiotics to three-quarters of
patients who consult with a lower respiratory tract illness (LRTi). In spite of this management, …

HiNF-P Directly Links the Cyclin E/CDK2/p220NPAT Pathway to Histone H4 Gene Regulation at the G1/S Phase Cell Cycle Transition

A Miele, CD Braastad, WF Holmes, P Mitra… - … and cellular biology, 2005 - Taylor & Francis
Genome replication in eukaryotic cells necessitates the stringent coupling of histone
biosynthesis with the onset of DNA replication at the G 1 /S phase transition. A fundamental …

[HTML][HTML] Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells

…, C Malcuit, O Kashpur, D Kole, WF Holmes… - The International …, 2010 - ncbi.nlm.nih.gov
The transcription factor NANOG is essential for maintaining pluripotency in embryonic stem
cells. We have previously reported the expression of NANOG in adult human fibroblasts; …

Information about migraine disability influences physicians' perceptions of illness severity and treatment needs

WF Holmes, EA MacGregor… - … : The Journal of Head …, 2001 - Wiley Online Library
Objective.—To assess physician‐patient communication about headache‐related disability
and to evaluate the influence of information about disability on physicians' perceptions of …