[HTML][HTML] Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling

W Heymann, J Glaser, F Schlegel, W Johnson… - … of Chromatography A, 2022 - Elsevier
Least squares estimation of unknown parameters from measurement data is a well-established
standard method in chromatography modeling but can suffer from critical disadvantages. …

Demographics, comorbidities and outcomes in hospitalized Covid-19 patients in rural southwest Georgia

…, J Owens, J Franklin, A Mehta, W Heymann… - Annals of …, 2020 - Taylor & Francis
Background There is limited data on outcomes in patients with coronavirus disease 2019 (Covid-19)
in rural United States (US). This study aimed to describe the demographics, and …

Robust mechanistic modeling of protein ion-exchange chromatography

V Kumar, S Leweke, W Heymann, E von Lieres… - … of Chromatography A, 2021 - Elsevier
Mechanistic models for ion-exchange chromatography of proteins are well-established and
a broad consensus exists on most aspects of the detailed mathematical and physical …

Multi-state steric mass action model and case study on complex high loading behavior of mAb on ion exchange tentacle resin

J Diedrich, W Heymann, S Leweke, S Hunt… - … of Chromatography A, 2017 - Elsevier
Tentacle resins for IEX are increasingly applied in preparative chromatography for their higher
selectivity and higher capacities in comparison to IEX resins without tentacles. However, …

[HTML][HTML] Jellyfish stings and their management: a review

L Cegolon, WC Heymann, JH Lange, G Mastrangelo - Marine drugs, 2013 - mdpi.com
Jellyfish (cnidarians) have a worldwide distribution. Despite most being harmless, some
species may cause local and also systemic reactions. Treatment of jellyfish envenomation is …

[HTML][HTML] The Italian national surveillance system for occupational injuries: Conceptual framework and fatal outcomes, 2002–2016

…, U Fedeli, M Pellicci, WC Heymann… - International journal of …, 2020 - mdpi.com
Background: A national database of work-related injuries has been established in Italy since
2002, collecting information on the injured person, his/her work tasks, the workplace and …

Advanced error modeling and Bayesian uncertainty quantification in mechanistic liquid chromatography modeling

W Heymann, J Glaser, F Schlegel, W Johnson… - … of Chromatography A, 2023 - Elsevier
Current mechanistic chromatography process modeling methods lack the ability to account
for the impact of experimental errors beyond detector noise (eg pump delays and variable …

[HTML][HTML] Improving Italian general practice training: the role of academia

L Cegolon, WC Heymann, JH Lange, C Xodo - BJGP open, 2017 - bjgpopen.org
Background The modern Italian national health service is a Beveridgean system centred
around GPs and funded by central taxation. 1, 2 In order to become eligible to work as a GP, …

International primary care snapshot: academic primary care in Italy

L Cegolon, W Heymann - British Journal of General Practice, 2016 - bjgp.org
Family medicine (also known as general practice or primary health care) has undergone
substantial growth accompanied by academic development in Western countries during recent …

[HTML][HTML] Compartment Model of Mixing in a Bubble Trap and Its Impact on Chromatographic Separations

J Beck, W Heymann, E von Lieres, R Hahn - Processes, 2020 - mdpi.com
Chromatography equipment includes hold-up volumes that are external to the packed bed
and usually not considered in the development of chromatography models. These volumes …