Metformin, a drug widely used in the treatment of type 2 diabetes, has recently been shown
to act on skeletal muscle and liver in part through the activation of AMP-activated protein …

Context: Obstructive sleep apnea (OSA) is a common condition with significant
cardiovascular and metabolic comorbidity. We hypothesized that these may result from OSA-induced …

… Paul Gee, Sandra Richardson, Wolfram Woltersdorf, Grant Moore … Author information:
Paul Gee, Emergency Physician, Emergency Department, Christchurch Hospital; Sandra …

A complex dynamic ultradian rhythm underlies the hypothalamic–pituitary–adrenal (HPA)
circadian rhythm. We have investigated in normal human male subjects the importance, site of …

Normal thyroid function is essential for health, but its genetic architecture remains poorly
understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4), we …

Humoral immunity to the Severe Adult Respiratory Syndrome (SARS) Coronavirus (CoV)‐2
is not fully understood yet but is a crucial factor of immune protection. The possibility of …

Context: Free T 3 (FT 3 ) has been positively associated with body mass index (BMI) in cross-sectional
studies in healthy individuals. This is difficult to reconcile with clinical findings in …

Background Laboratory tests are extensively used for diagnosis and monitoring in UK primary
care. Test usage by GPs, and associated costs, have grown substantially in recent years. …

The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic
ultradian rhythm of plasma cortisol that underlies the classical circadian rhythm. These …

Apelin is a peptide hormone with cardiovascular and glucose homeostasis properties, and
obstructive sleep apnea (OSA) is complicated by cardiovascular and metabolic comorbidities. …