Objective To develop and validate version two of the QRISK cardiovascular disease risk
algorithm (QRISK2) to provide accurate estimates of cardiovascular risk in patients from different …

Objective To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom
and to validate its performance against the established Framingham cardiovascular …

Objective To assess the association between risk of venous thromboembolism and use of
different types of hormone replacement therapy. Design Two nested case-control studies. …

Objective To investigate the associations between direct oral anticoagulants (DOACs) and
risks of bleeding, ischaemic stroke, venous thromboembolism, and all cause mortality …

Objective To investigate the association between use of combined oral contraceptives and
risk of venous thromboembolism, taking the type of progestogen into account. Design Two …

Aim: To assess the performance of the QRISK score for predicting cardiovascular disease (CVD)
in an independent UK sample from general practice and compare with the Framingham …

Context There is conflicting evidence on whether people with schizophrenia have a different
risk of cancer from that of the general population. Objective To determine the risk of 6 …

Objective To assess the risks of breast cancer associated with different types and durations
of hormone replacement therapy (HRT). Design Two nested case-control studies. Setting UK …

1 Abstract Background Many studies and meta-analyses have investigated the effects of
statins on cancer incidence but without showing consistent effects. Methods A series of nested …

Objectives To estimate rates of discontinuation and restarting of statins, and to identify patient
characteristics associated with either discontinuation or restarting. Design Prospective …