The discovery of mis-sense mutations in the α1A subunit of the P/Q-type calcium channel in
patients with familial hemiplegic migraine indicates the potential involvement of …

It is considered that the site of action of the abortive antimigraine compounds acting at
serotonin, 5‐HT 1B/1D, receptors (triptans) is the trigeminovascular system. We tested whether …

Patients with primary headache syndromes often describe a distribution of pain that involves
both frontal and occipital parts of the head. Such a distribution of pain does not respect the …

Clinical observations, particularly of the premonitory phase of migraine, suggest the
involvement of the hypothalamus in the earliest phases of an attack. Stimulation of the superior …

1 The observation that 5‐hydroxytryptamine (5‐HT) is effective in treating acute attacks of
migraine when administered intravenously resulted in a research effort that led to the discovery …

Functional imaging studies and clinical evidence suggest that structures in the brainstem
contribute to migraine pathophysiology with a strong association between the brainstem areas, …

The cranial circulation, both extracerebral and cerebral, is innervated by fibers from the
trigeminal nerve. This system is known as the trigeminovascular system. The large venous …

We have recently shown that injection of the P/Q-type (Ca v 2.1/α 1A ) calcium channel blocker,
ω-agatoxin IVA, into the periaqueductal gray (PAG) facilitates meningeal dural stimulation…

Bringing about change in teaching and learning in higher education is a core aspect of the
work of academic developers. This paper is novel in analysing the experience of a year-long …

Planet issue 21 December 2008 builds a more uncertain and complicated picture. Karl
Mannheim (1952) was the first modern academic to investigate the development of generational …